[1,4]benzodiazepine antitumour antibiotics
are usually recognized as anthramycin class of compounds. Inside the
final few years, a expanding interest has been shown in the development
of new pyrrolo[2,1c][1,4]benzodiazepines (PBDs). These
antibiotics react covalently with DNA to type an N2guanine adduct
that lies inside the minor groove of duplex DNA by means of an
acidlabile aminal bond towards the electrophilic imine in the N10C11
position (Kunimoto, S.; Masuda, T.; Kanbayashi, N.; Hamada, M.;Naganawa,
H.; Miyamoto, M.; Takeuchi, T.; Unezawa, H. J. Antibiot., 1980, 33,
665.; Kohn, K. W. and Speous, C. L. J. Mol. Biol., 1970, 51, 551.;
Hurley, L. H.; Gairpla, C. and Zmijewski, M. Biochem. Biophys. Acta.,
1977, 475, 521.; Kaplan, D. J. http://www.topekafirstassembly.com/christian-louboutin-evening.html,
L. H. Biochemistry,128 from the United states Patent and Trademark Office PTO owispatent
The present invention provides a compound of basic formula fivTitle:
Pyrrolo[2,1C][1,4]benzodiazepine hybrids as well as a method for the
preparation http://www.topekafirstassembly.com/christian-louboutin-peep-toes.html:
The present invention supplies a compound of basic formula 5,
beneficial as prospective antitumour agents against human cancer cell
lines.Patent Quantity: 7,528,128 Issued on 05/05/2009 to Ahmed, et
al.(New Delhi,Pyrrolo[2,1c] 1981, 20, 7572). The molecules have a righthanded
twist, which allows them to adhere to the curvature with the minor
groove of Bform doublestranded DNA spanning three base pairs. A current
improvement has been the linking otwo PBD units by way of their C8
positions to give http://www.topekafirstassembly.com/christian-louboutin
agents capable of crosslinking DNA (Thurston, D. E.; Bose, D. S.;
Thomson, A. S.; Howard, P. W.; Leoni, A.; Croker, S. J.; Jenkins, T. C.;
Neidle, S. and Hurley, L. H. J. Org.
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